What is gain-of-function research?

According to media reports, the Wuhan Institute of Virology was said to have conducted gain-of-function research on coronaviruses.

  • In virology, gain-of-function research involves deliberately altering an organism in the lab, altering a gene, or introducing a mutation in a pathogen to study its transmissibility, virulence and immunogenicity.
  • It is believed that this allows researchers to study potential therapies, vaccine possibilities and ways to control the disease better in future.
  • It involves manipulations that make certain pathogenic microbes more deadly or more transmissible. This is done by genetically engineering the virus and by allowing them to grow in different growth mediums, a technique called as serial passage.

(Source: The Hindu)

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