A study, published in the journal Science Advances, has revealed for the first time the mechanism responsible for blood clots arising from thrombosis with thrombocytopenia syndrome (TTS) following vaccination with AstraZeneca vaccine.
What is TTS?
- The TTS is characterised by thrombosis formation (blood clots) combined with thrombocytopenia (low platelet count).
- A low number of platelets – blood cells that help prevent blood loss when vessels are damaged – can result in no symptoms or can lead to an increased risk of bleeding or, in some cases, clotting.
Very rare serious adverse effect
- Thrombosis with thrombocytopenia syndrome is a very rare serious adverse effect following vaccination using chimpanzee adenovirus Y25 (ChAdOx1), human adenovirus type 26 (HAdV-D26), and human adenovirus type 5 (HAdV-C5).
Adenovirus
- AstraZeneca vaccine and the Indian counterpart Covishield use the chimpanzee adenovirus Y25, while Johnson & Johnson vaccine uses the human adenovirus type 26.
- The Sputnik vaccine uses both human adenovirus type 26 and human adenovirus type 5 as vectors to ferry the spike protein into certain cells.
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