R21/Matrix M: A malaria vaccine candidate

According to the the Lancet, a malaria vaccine candidate has shown promise in phase 2b clinical trials, with high efficacy at 77 per cent.

  • The new vaccine candidate, called R21/Matrix M, is a modified version of RTS, S — another candidate against malaria that has been in development for more than 30 years by Walter Reed Institute of Research, GlaxoSmithKline and Bill and Melinda Gates Foundation with the PATH Malaria Vaccine Initiative.
  • This vaccine is designed to stop the Plasmodium falciparum malaria parasite from entering the liver and preventing the subsequent deadly blood stages.
  • Thirty years in the making, RTS,S is the first, and to date the only, vaccine to reduce malaria in children. But it is not highly efficacious.

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