Organs-on-chips (OoCs) are systems containing engineered or natural miniature tissues grown inside microfluidic chips. OoCs are used for mimicking the human body environment.
- To better mimic human physiology, the chips are designed to control cell microenvironments and maintain tissue-specific functions.
- The goal for organ-on-a-chip is to develop human tissue models for disease modeling and drug testing.
- They use microfluidics, along with cells, to imitate the physiological and mechanical conditions experienced in the body.
- They can control the movement and behavior of materials and cells by using channels, chambers, membranes, etc.
- The devices are manufactured using soft lithography and BioMEMS (BioMicroElectroMechanical Systems), which allow for the micro scale details to be properly produced.
- These fabrication techniques allow the use of different materials, including thermoplastics and thermoset polymers.
