Researchers from the Institute of Advanced Study in Science and Technology (IASST) has fabricated a new flexible bio-electronic uric acid detecting device that can be used for various applications such as wearable sensors and point-of-care diagnostics.
Key points
The flexible bio-electronic uric acid detecting device made up of reduced phosphorene quantum dots — a new class of zero-dimensional functional nanostructures with unique physicochemical and surface properties.
- The quantum dots show distinctive electrical performance in biomedical applications and so can be used in fabricating high-performance electrical biosensors.
Key points
- Uric acid is one of the most important antioxidants that maintain blood pressure stability and reduce oxidative stress in living beings.
- The usual range of uric acid in blood ranges from 0.14 to 0.4 mmol dm-3, and for urine, 1.5 to 4.5 mmol dm-3.
- However, the fluctuation of uric acid levels due to the lack of balancing between the production and excretion causes several diseases like hyperuricemia, which in turn may lead to gout disease, type 2 diabetes, increase risk of cardiovascular diseases, Lesch–Nyhan syndrome, hypertension, and renal disorders.
- The current-voltage and the impedance (opposition electron flow) responses for the fabricated device have been studied with increased uric acid concentration.
- With the increase in uric acid concentration, the current density increases and shows a maximum current of about 1.35 ×10-6 A.
